The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics , Metabolism , and Excretion of the Antiviral Drug 1 Arbidol in Humans
Pharmacokinetics, Metabolism, and Excretion of the Antiviral Drug 1 Arbidol in Humans 2 3 Pan Deng, Dafang Zhong, Kate Yu, Yifan Zhang, Ting Wang, and Xiaoyan Chen 4 5 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 6 Waters Corporation, MA, USA; and First Affiliated Hospital of Lanzhou University, Lanzhou, 7 China 8 9
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The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane. To better understand Arb mechanism of action, we investigated its interactions with phospholipids and membrane peptides. We demonstrate that Arb associates with phospholipids in the micromolar range. NMR reveals that Arb interacts with the polar head-group of pho...
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The broad-spectrum antiviral drug Arbidol shows efficacy against influenza viruses by targeting the hemagglutinin (HA) fusion machinery. However, the structural basis of the mechanism underlying fusion inhibition by Arbidol has remained obscure, thereby hindering its further development as a specific and optimized influenza therapeutic. We determined crystal structures of Arbidol in complex wit...
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Salts of the antiviral drug arbidol (umifenovir) (Arb) with maleate (Mlc) and fumarate (Fum) anions have been obtained, and their crystal structures have been described. The crystal structure of arbidol maleate has been redetermined by single crystal X-ray diffraction at 180K. A new arbidol cocrystal in zwitterion form with succinic acid (Suc) has also been found and characterized. The arbidol ...
متن کاملArbidol: a broad-spectrum antiviral compound that blocks viral fusion.
Arbidol (ARB; ethyl-6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-indole-3-carboxylate hydrochloride monohydrate), is a Russian-made potent broad-spectrum antiviral with demonstrated activity against a number of enveloped and non-enveloped viruses. ARB is well known in Russia and China, although to a lesser extent in western countries. Unlike other broad-spectrum a...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2016
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.02077-15